Manchester Road, which is maintained by the Missouri Department of Transportation
, was reconstructed in 2002 with the new split road configuration that features separate four lane eastbound and westbound roadways from Barrett Station Road to Interstate 270.
The opening of Interstate 270 with its exit at Manchester Road in 1965 marked the beginning of Des Peres' transition from an agriculturally based area (greenhouses) to its modern day place of commerce. Old greenhouses and family homes began to give way to more modern developments.
A State Charter was issued for Colonial Bank - the first bank in Des Peres. In 1967, Eime's Greenhouses gave way to what is now Des Peres Commons Shopping Center. The year 1969 saw development of Colonnade Center and the conversion of the Manchester Road Drive-In into the West County Shopping Center.